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Researchers succeed in building protein nanotubes from tiny scaffolds
Researchers at Tokyo Institute of Technology (Tokyo Tech) have succeeded in constructing protein nanotubes from tiny scaffolds made by cross linking of engineered protein crystals. canada goose outlet uk sale The achievement could accelerate the development of artificial enzymes, nano sized carriers and delivery systems for a host of biomedical and biotechnological applications.
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canada goose coats Scientists have faced challenges in constructing protein assemblies in aqueous solution due to the disorganized ways in which proteins interact freely under varying conditions such as pH and temperature. canada goose coats
cheap canada goose uk The new method, canada goose outlet london reported in goose outlet canada the journal Chemical Science, overcomes these problems by using protein crystals, which serve as a promising scaffold for proteins to self assemble into desired structures. The method has four steps, as illustrated in Construction of nanotubes from protein crystals: cheap canada goose uk
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buy canada goose jacket The researchers chose a naturally occurring protein called RubisCO as a building canada goose victoria parka outlet block for construction of nanotube. Due to its high stability, RubisCO could keep its shape, and its crystal structure canada goose jacket outlet from previous research had recommended canada goose outlet store uk it for this study. buy canada goose jacket
canada goose uk outlet Using Transmission Electron Microscopy canada goose outlet montreal (TEM) imaging at Tokyo Tech Suzukakedai Biomaterials Analysis Division, the team successfully confirmed canada goose parka uk the formation of the protein nanotubes. canada goose uk outlet
The study also demonstrated that the protein nanotubes could retain their enzymatic ability.
Canada Goose Coats On Sale “Our cross linking method can facilitate the formation of the crystal scaffold efficiently at the desired position (specific cysteine sites) within each tubes of the crystal,” canada goose outlet vancouver says Ueno. “At present, since canada goose vest outlet more than 100,000 protein crystal structures have been deposited in Protein data bank, our method can be applied to other protein crystals for construction of supramolecular protein assemblies, such as cages, tubes, sheets.” Canada Goose Coats On Sale
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